Gene information
Official symbol COMT
Official full name catechol-O-methyltransferase
Gene type protein-coding gene
Chromosome22q11.21
Gene familySeven-beta-strand methyltransferase motif containing; MicroRNA protein coding host genes
Resources
Entrez Gene 1312
HGNC HGNC:2228
Ensembl ENSG00000093010
Vega OTTHUMG00000150529
UCSC uc002zqu.4
GO terms: 14 records
GO Description Category LogP Number of genes Detail
GO:0001505 regulation of neurotransmitter levels GO Biological Processes -3.63969141 10 More
GO:0009267 cellular response to starvation GO Biological Processes -4.23113258 19 More
GO:0009991 response to extracellular stimulus GO Biological Processes -42.2178323 102 More
GO:0030424 axon GO Cellular Components -6.14132550 54 More
GO:0030425 dendrite GO Cellular Components -4.55233052 48 More
GO:0031667 response to nutrient levels GO Biological Processes -41.8130555 98 More
GO:0031668 cellular response to extracellular stimulus GO Biological Processes -10.2327580 36 More
GO:0031669 cellular response to nutrient levels GO Biological Processes -9.42886914 32 More
GO:0042594 response to starvation GO Biological Processes -5.43370462 24 More
GO:0071496 cellular response to external stimulus GO Biological Processes -17.0078490 52 More
GO:0097447 dendritic tree GO Cellular Components -4.82959150 49 More
GO:1901361 organic cyclic compound catabolic process GO Biological Processes -2.75406624 12 More
GO:1901615 organic hydroxy compound metabolic process GO Biological Processes -22.7091625 41 More
GO:1901616 organic hydroxy compound catabolic process GO Biological Processes -5.34432635 8 More
KEGG pathways: 2 records
KEGG Description Category LogP Number of genes Detail
hsa00350 Tyrosine metabolism KEGG Pathway -3.07164259 4 More
hsa04728 Dopaminergic synapse KEGG Pathway -2.98664168 7 More
Drug-Gene interaction
view
Related drugs: 32 records
Drug name Interaction type Source PMID View
benztropine PharmGKB view
buprenorphine PharmGKB 30549211 view
bupropion PharmGKB 16876132 view
cisplatin PharmGKB 198984822844518823820299251419532464273523588304284486572856085425551397 view
clozapine PharmGKB 25560469 view
diacetylmorphine PharmGKB view
entacapone inhibitor TdgClinicalTrialChemblInteractionsTENDPharmGKBTTD 128762371043993511939936109812531187393812538800114402839808337108821601175235221280081 view
fentanyl PharmGKB 3028192430549211 view
fluvoxamine PharmGKB 20619611 view
haloperidol PharmGKB 2702343723963056 view
levodopa PharmGKB view
lithium PharmGKB view
methadone PharmGKB 28006928324071522368633021398039233029852690264329474345237733412515593125185591195141302874557727027462 view
methyldopa PharmGKB view
methylphenidate PharmGKB 2923002323131881247631831821486518703939221494702403525521550019 view
modafinil PharmGKB 93525699631418119903841595698812605099123596901246507311840516 view
morphine PharmGKB 1105476612595695280069281592739123686330213980392330298526902643294743452377334192593812515593125185591195141302874557727027462 view
nicotine PharmGKB 1819289822695756265553321192784216395295 view
norepinephrine PharmGKB view
olanzapine PharmGKB view
opicapone antagonistinhibitor TTD 2749819916690967 view
oxycodone PharmGKB 280069282368633021398039233029852690264329474345237733412515593125185591195141302874557727027462 view
paroxetine PharmGKB 18989660 view
quetiapine PharmGKB 26282453 view
remifentanil PharmGKB 280069282368633021398039233029852690264329474345237733412515593125185591195141302874557727027462 view
risperidone PharmGKB 1945191522935916 view
sertraline PharmGKB view
sufentanil PharmGKB 280069282368633021398039233029852690264329474345237733412515593125185591195141302874557727027462 view
sumatriptan PharmGKB 25096645 view
tolcapone inhibitor TdgClinicalTrialChemblInteractionsTENDTTD 17063156118739381253880018046910980833710882160117523521950377320502133156973299917075 view
trihexyphenidyl PharmGKB view
venlafaxine PharmGKB 224179332862777623706899 view
Related study: 1 record
Molecular factor Omics type Application Objective MI type Reference
NM_000754.4:c.472G>A genomics myocardial infarction[diagnosis] myocardial infarction Eriksson AL et al. Eur Heart J. 2004
All rights reserved: Soochow University Center for Systems Biology